The main goal of our research is to understand how coordinated motor functions emerge from the integration of various sensory inputs (visual, proprioceptive, vestibular), and how the neural elements responsible for this multimodal integration adapt to perturbations such as lesions, mutations, or environmental changes. In particular, our research is focused on the vestibular system responsible not only for the sense of balance, e.g. gaze and posture stabilization, but as we have shown in humans, also constitute a primary input into other sensorimotor behaviors including visual perception and eye-hand coordination.

Our expertise on the basic science of sensorimotor integration is transferable into more applied fields as well. First, the team is actively working with the CNES, ESA and NASA to understand how sensorimotor integration adapts to weightlessness. Second, our understanding of the physiology of the vestibular system leads to the development of experimental models of human motion sickness or vestibular-related pathologies.

The team is developing an integrative approach based on cellular and network models, in vitro electrophysiology on slices, and behavioral and electrophysiological studies in animals and humans. We welcome students or collaborators who share our goals and enthusiasm for the following themes of research:

Research Themes

1. Context-specific behavioral strategies and adaptation to environmental changes:
   • Modulation of vestibulo-ocular and optokinetic reflexes.
   • Gravity’s influence on sensorimotor transformations.
   • Adaptation to hypergravity and weightlessness.
2. Visuo-vestibular interactions and adaptation to sensory conflicts:
   • Dynamic of synaptic and intrinsic changes in vestibular adaptation.
   • Integration of vestibular and visual inputs for orientation: head direction cells.
   • Eye-hand coordination.
3. Inner ear and central vestibular pathologies:
   • Developmental pathologies (congenital nystagmus; scoliosis; foetal cytomegalovirus syndrome; benign paroxys mal positional vertigo).
   • Acquired pathologies (Aged-related acuity loss; vestibular lesions).
   • Motion sickness and neuromodulation.

Collaborations

• INRIA Rhônes-Alpes (Grenoble; France).
• Mouse Clinical institute and IGBMC (Strasbourg; France).
• French and European space agencies.
• Istituto Italiano di Tecnologia (Genova; Italy).
• Politecnico di Milano (Milan; Italy).
• Tecnalia Health Technologies (San Sebastian; Spain).
• Delft University of Technology (Delft; Holland).
• University at Buffalo (Buffalo; US).

Former members

See the list of former members

Recent Publications

2017 :

• A strategy of faster movements used by elderly humans to lift objects of increasing weight in ecological context.
  Hoellinger T, McIntyre J, Jami L, Hanneton S, Cheron G, Roby-Brami A : Neuroscience, 2017
• The visual encoding of purely proprioceptive intermanual tasks is due to the need of transforming joint signals, not to their interhemispheric transfer.
  Arnoux L, Fromentin S, Farotto D, Beraneck M, McIntyre J, Tagliabue M : J Neurophysiol, 2017
• Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G.
  Emptoz A, Michel V, Lelli A, Akil O, Boutet de Monvel J, Lahlou G, Meyer A, Dupont T, Nouaille S, Ey E, Franca de Barros F, Beraneck M, Dulon D, Hardelin JP, Lustig L, Avan P, Petit C, Safieddine S : Proc Natl Acad Sci U S A, 2017
• AhR-deficiency as a cause of demyelinating disease and inflammation.
  Juricek L, Carcaud J, Pelhaitre A, Riday TT, Chevallier A, Lanzini J, Auzeil N, Laprévote O, Dumont F, Jacques S, Letourneur F, Massaad C, Agulhon C, Barouki R, Beraneck M, Coumoul X : Sci Rep, 2017
• Laminar Localization and Projection-Specific Properties of Presubicular Neurons Targeting the Lateral Mammillary Nucleus, Thalamus or Medial Entorhinal Cortex
  Huang LW*, Simonnet J*, Nassar M, Richevaux L, Lofredi R, Fricker D : ENeuro, 2017
• How activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum
  Simonnet J, Nassar M, Stella F, Cohen I, Mathon B, Boccara CN, Miles R, Fricker D : BioRxiv - Accepted for publication in Nature Communications -, 2017
• Long-Lasting Visuo-Vestibular Mismatch in Freely-Behaving Mice Reduces the Vestibulo-Ocular Reflex and Leads to Neural Changes in the Direct Vestibular Pathway.
  Carcaud J, França de Barros F, Idoux E, Eugène D, Reveret L, Moore LE, Vidal PP, Beraneck M : ENeuro, 2017

2016 :

• Mechanisms of sodium channel clustering and its influence on axonal impulse conduction.
  Freeman SA, Desmazières A, Fricker D, Lubetzki C, Sol-Foulon N : Cell Mol Life Sci, 2016
• Auditory and visual 3D virtual reality therapy as a new treatment for chronic subjective tinnitus: Results of a randomized controlled trial.
  Malinvaud D, Londero A, Niarra R, Peignard P, Warusfel O, Viaud-Delmon I, Chatellier G, Bonfils P : Hear Res, 2016
• Physiological mechanisms for stabilizing the limb when acting against physical constraints.
  Senot P, Damm L, Tagliabue M, McIntyre J : Conf Proc IEEE Eng Med Biol Soc, 2016

2015 :

• Acceleration of conduction velocity linked to clustering of nodal components precedes myelination.
  Freeman SA, Desmazières A, Simonnet J, Gatta M, Pfeiffer F, Aigrot MS, Rappeneau Q, Guerreiro S, Michel PP, Yanagawa Y, Barbin G, Brophy PJ, Fricker D, Lubetzki C, Sol-Foulon N : Proc Natl Acad Sci U S A, 2015
• Diversity and overlap of parvalbumin and somatostatin expressing interneurons in mouse presubiculum.
  Nassar M, Simonnet J, Lofredi R, Cohen I, Savary E, Yanagawa Y, Miles R, Fricker D : Front Neural Circuits, 2015
• Increasing the effectiveness of intracerebral injections in adult and neonatal mice: a neurosurgical point of view.
  Mathon B, Nassar M, Simonnet J, Duigou CL, Clemenceau S, Miles R, Fricker D : Neurosci Bull, 2015
• Perception of affordances during long-term exposure to weightlessness in the International Space station.
  Bourrelly A, McIntyre J, Luyat M : Cogn Process, 2015
• Physiological modules for generating discrete and rhythmic movements: component analysis of EMG signals.
  Bengoetxea A, Leurs F, Hoellinger T, Cebolla AM, Dan B, Cheron G, McIntyre J : Front Comput Neurosci, 2015
• Differences between kinematic synergies and muscle synergies during two-digit grasping.
  Tagliabue M, Ciancio AL, Brochier T, Eskiizmirliler S, Maier MA : Front Hum Neurosci, 2015
• An uncommon cause of allergic fungal sinusitis: Rhizopus oryzae.
  Devars du Mayne M, Gratacap M, Malinvaud D, Grenouillet F, Bonfils P : Ear Nose Throat J, 2015
• Blood brain barrier precludes the cerebral arteries to intravenously-injected antisense oligonucleotide.
  Boursereau R, Donadieu A, Dabertrand F, Dubayle D, Morel J : Eur J Pharmacol, 2015

2014 :

• Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network.
  Le Duigou C, Simonnet J, Teleñczuk MT, Fricker D, Miles R : Front Cell Neurosci, 2014
• An organotypic brain slice preparation from adult patients with temporal lobe epilepsy.
  Eugène E, Cluzeaud F, Cifuentes-Diaz C, Fricker D, Le Duigou C, Clemenceau S, Baulac M, Poncer JC, Miles R : J Neurosci Methods, 2014
• Physiological modules for generating discrete and rhythmic movements: action identification by a dynamic recurrent neural network.
  Bengoetxea A, Leurs F, Hoellinger T, Cebolla AM, Dan B, McIntyre J, Cheron G : Front Comput Neurosci, 2014
• Postoperative Hemorrhage After Transoral Oropharyngectomy for Cancer of the Lateral Oropharynx.
  Laccourreye O, Malinvaud D, Garcia D, Ménard M, Hans S, Cauchois R, Bonfils P : Ann Otol Rhinol Laryngol, 2014
• Total laryngectomy or laryngeal preservation for advanced laryngeal cancer. Impact of the functional risk upon the patient’s preferences.
  Laccourreye O, Malinvaud D, Ménard M, Consoli S, Giraud P, Bonfils P : Eur Ann Otorhinolaryngol Head Neck Dis, 2014
• Unilateral laryngeal nerve paralysis in the adult : Epidemiology, symptoms, physiopathology and treatment
  Laccourreye O, Malinvaud D, Ménard M, Bonfils P : Presse Med, 2014
• A modular theory of multisensory integration for motor control. Frontiers in Computational Neuroscience
  Tagliabue M, McIntyre J : Front Comput Neurosci, 2014
• Gravity influences top-down signals in visual processing
  Cheron G, Leroy A, Palmero-Soler E, De Saedeleer C, Bengoetxea A, Cebolla A M, Vidal M, Dan B, Berthoz A, McIntyre J : PLoS One, 2014

2013 :

• Cellular neuroanatomy of rat presubiculum.
  Simonnet J, Eugène E, Cohen I, Miles R, Fricker D : Eur J Neurosci, 2013
• First bite syndrome.
  Laccourreye O, Werner A, Garcia D, Malinvaud D, Tran Ba Huy P, Bonfils P : Eur Ann Otorhinolaryngol Head Neck Dis, 2013
• Late recurrence or secondary location? Towards a better understanding of the physiopathology of inverted papilloma.
  Prud’homme C, Espinoza S, Badoual C, Laccourreye O, Bonfils P, Malinvaud D : Eur Ann Otorhinolaryngol Head Neck Dis, 2013
• Lateral pharyngotomy for selected invasive squamous cell carcinoma of the lateral oropharynx--part I: how.
  Laccourreye O, Benito J, Menard M, Garcia D, Malinvaud D, Holsinger C : Laryngoscope, 2013
• Perfusion in ENT imaging.
  Espinoza S, Malinvaud D, Siauve N, Halimi P : Diagn Interv Imaging, 2013
• Glottic bamboo nodules from systemic lupus erythematosus.
  Malinvaud D, Mukundan S, Crevier-Buchman L, Bonfils P, Laccourreye O : Ann Otol Rhinol Laryngol, 2013
• Cystic lesions of the pterygoid process.
  El Amri G, Malinvaud D, Laccourreye O, Bonfils P : Eur Ann Otorhinolaryngol Head Neck Dis, 2013
• Restricted neural plasticity in vestibulospinal pathways after unilateral labyrinthectomy as the origin for scoliotic deformations
  Lambert FM, Malinvaud D, Gratacap M, Straka H, Vidal PP : J Neurosci, 2013
• Keep your head on straight : facilitating sensori-motor transformations for eye-hand coordination
  Tagliabue M, Arnoux L, McIntyre J : Neuroscience, 2013
• HCN1 channels in cerebellar Purkinje cell promote late stages of learning and constrain synaptic inhibition
  inaldi A, Defterali C, Mialot A, Garden DLF, Beraneck M, Nolan MF : J Physiol, 2013
• Weightlessness alters up/down asymmetries in the perception of self-motion.
  De Saedeleer C, Vidal M, Lipshits M, Bengoetxea A, Cebolla A M, Berthoz A, Cheron G, McIntyre J : Exp Brain Res, 2013
• Task dependency of grip stiffness–a study of human grip force and grip stiffness dependency during two different tasks with same grip forces
  Höppner H, McIntyre J, Van Der Smagt P : PLoS One, 2013
• A focus on mast cells and pain
  Héron A, Dubayle D : J Neuroimmunol, 2013
• Retinoic acid deficiency impairs the vestibular function.
  Romand R, Krezel W, Beraneck M, Cammas L, Fraulob V, Messaddeq N, Kessler P, Hashino E, Dollé P : J Neurosci, 2013
• When kinesthesia becomes visual: a theoretical justification for executing motor tasks in visual space.
  Tagliabue M, McIntyre J : PLoS One, 2013
• Oculomotor deficits in aryl hydrocarbon receptor null mouse.
  Chevallier A, Mialot A, Petit JM, Fernandez-Salguero P, Barouki R, Coumoul X, Beraneck M : PLoS One, 2013

2012 :

• Cellular anatomy, physiology and epileptiform activity in the CA3 region of Dcx knockout mice: a neuronal lamination defect and its consequences.
  Bazelot M, Simonnet J, Dinocourt C, Bruel-Jungerman E, Miles R, Fricker D, Francis F : Eur J Neurosci, 2012
• Inverted papilloma of the middle ear.
  Rubin F, Badoual C, Moya-Plana A, Malinvaud D, Laccourreye O, Bonfils P : Eur Ann Otorhinolaryngol Head Neck Dis, 2012
• Sinus mucocele: natural history and long-term recurrence rate.
  Devars du Mayne M, Moya-Plana A, Malinvaud D, Laccourreye O, Bonfils P : Eur Ann Otorhinolaryngol Head Neck Dis, 2012
• Trade-off between survival and laryngeal preservation in advanced laryngeal cancer: the otorhinolaryngology patient’s perspective.
  Laccourreye O, Malinvaud D, Holsinger FC, Consoli S, Ménard M, Bonfils P : Ann Otol Rhinol Laryngol, 2012
• Conventional transoral surgery for stage I-II squamous cell carcinoma of the tonsillar region.
  Laccourreye O, Malinvaud D, Alzahrani H, Ménard M, Garcia D, Bonfils P, Holsinger FC : Head Neck, 2012
• Extraosseous plasmacytoma of the lacrimal duct.
  Malinvaud D, Badoual C, Rubio MT, Halimi P, Bonfils P : B-ENT, 2012
• Intraparotid Kimura disease.
  Bonfils P, Moya-Plana A, Badoual C, Nadéri S, Malinvaud D, Laccourreye O : Eur Ann Otorhinolaryngol Head Neck Dis, 2012
• Eye-hand coordination when the body moves : dynamic egocentric and exocentric sensory encoding
  Tagliabue M, McIntyre J : Neurosci Lett, 2012
• When up is down in 0g : how gravity sensing affects the timing of interceptive actions
  Senot P, Zago M, Le Séac’h A, Zaoui M, Berthoz A, Lacquaniti F, McIntyre J : J Neurosci, 2012
• Auditory outcomes after implantation and electrical stimulation of the lateral ampullar nerve in guinea pig
  Tran H, De Waele C, Beraneck M, Vassias I, Gioanni H, Huy PTB, Herman P, Vidal PP, Kania RE : Ear Hear, 2012
• Reconsidering the role of neuronal intrinsic properties and neuromodulation in vestibular homeostasis
  Beraneck M, Idoux E : Front Neurol, 2012
• Ontogeny of mouse vestibulo-ocular reflex following genetic or environmental alteration of gravity sensing
  Beraneck M, Bojados M, Le Séac’h A, Jamon M, Vidal PP : PLoS One, 2012
• Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide
  Dubayle D, Héron A : Inflamm Res, 2012

2011 :

• The 21(st) Ion Channel Meeting, September 2010, France.
  Baron-Foster A, Poët M, Pichon O, Fricker D, Poncer JC, Van Coppenolle F, Duranton C : Channels (Austin), 2011
• Reaching while standing in microgravity: a new postural solution to oversimplify movement control.
  Casellato C, Tagliabue M, Pedrocchi A, Papaxanthis C, Ferrigno G, Pozzo T : Exp Brain Res, 2011
• Sudden deafness following a sternutatory attack.
  Bonfils P, Laccourreye O, Durand FX, Malinvaud D, Bensimon JL : Eur Ann Otorhinolaryngol Head Neck Dis, 2011
• Olfactory system and emotion: common substrates.
  Soudry Y, Lemogne C, Malinvaud D, Consoli SM, Bonfils P : Eur Ann Otorhinolaryngol Head Neck Dis, 2011
• Pneumosinus dilatans associated with nasal polyposis.
  Malinvaud D, Halimi P, Bonfils P : B-ENT, 2011
• Pathophysiology of airway hyperresponsiveness in patients with nasal polyposis.
  Mahut B, Plantier L, Malinvaud D, Chevalier-Bidaud B, Bonfils P, Delclaux C : Respir Med, 2011
• Paralysie laryngée unilatérale de l’adulte
  Laccourreye O, Malinvaud D, Ménard M, Bonfils P : Rev Prat, 2011
• Olfactory system and emotion: common substrates. Les bases communes du système olfactif et des émotions
  Soudry Y, Lemogne C, Malinvaud D, Consoli SM, Bonfils P : Eur Ann Otorhinolaryngol Head Neck Dis, 2011
• A robotic model to investigate human motor control
  Lenzi T, Vitiello N, McIntyre J, Roccella S, Carrozza MC : Biol Cybern, 2011
• Vestibular signal processing by separate sets of neuronal filters
  Beraneck M, Straka H : J Vestib Res, 2011
• Intrinsic membrane properties of central vestibular neurons in rodents
  Eugène D, Idoux E, Beraneck M, Moore LE, Vidal PP : Exp Brain Res, 2011
• Gait transitions in simulated reduced gravity
  Ivanenko YP, Labini FS, Cappellini G, Macellari V, McIntyre J, Lacquaniti F : J Appl Physiol (1985), 2011
• Behavioral and neural correlates of communication via pointing
  Cleret de Langavant L, Remy P, Trinkler I, McIntyre J, Dupoux E, Berthoz A, Bachoud-Lévi AC : PLoS One, 2011
• Necessity is the mother of invention : Reconstructing missing sensory information in multiple, concurrent reference frames for eye-hand coordination
  Tagliabue M, McIntyre J : J Neurosci, 2011

Books, chapters and patents

• Method for quantifying the behaviour of an animal
  Beraneck M, Reveret L, Vidal PP : N° de brevet : WO2015/036495, 2015

• Estimation of two-digit grip type and grip force level by frequency decoding of motor cortex activity for a BMI application
  Tagliabue M, Francis, N, Hao Y, Duret M, Brochier T, Riehle A, Maier MA, Eskiizmirliler S : extrait de Proceedings of The 17th International Conference on Advanced Robotics (ICAR) 27 -31 July, 2015 Istanbul, Turkey Sinan Kalkan, Uluç Saranlı - ICAR International Conference, pages 308-315, ISBN:978-1-4673-7509-2, 2015
• Wearable Technologies for Automotive User Interfaces: Danger or Opportunity?
  Caon M, Tagliabue M, Angelini L, Perego P, Mugellini E, Andreoni G : extrait de Proceeding AutomotiveUI \\’14 Adjunct Proceedings of the 6th International Conference on Automotive User Interfaces and Interactive Vehicular Applications Linda Ng Boyle, Andrew L Kun, Sebastian Osswald, B - ACM, pages 1-5, ISBN:978-1-4503-0725-3, 2014
• Chapter 15 – Functional Development of the Vestibular System: Sensorimotor Pathways for Stabilization of Gaze and Posture
  Beraneck M, Lambert FM, Sadeghi SG : extrait de Development of Auditory and Vestibular Systems (Fourth Edition) Raymond Romand, Isabel Varela-Nieto - Academic Press, pages 449-487, ISBN:978-0-12-408088-1, 2014