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Sensorimotor Adaptations and Vestibular Pathologies

Sensorimotor adaptation team May 2016

The main goal of our research is to understand how coordinated motor functions emerge from the integration of various sensory inputs (visual, proprioceptive, vestibular), and how the neural elements responsible for this multimodal integration adapt to perturbations such as lesions, mutations, or environmental changes. In particular, our research is focused on the vestibular system responsible not only for the sense of balance, e.g. gaze and posture stabilization, but as we have shown in humans, also constitute a primary input into other sensorimotor behaviors including visual perception and eye-hand coordination.

Our expertise on the basic science of sensorimotor integration is transferable into more applied fields as well. First, the team is actively working with the CNES, ESA and NASA to understand how sensorimotor integration adapts to weightlessness. Second, our understanding of the physiology of the vestibular system leads to the development of experimental models of human motion sickness or vestibular-related pathologies.

The team is developing an integrative approach based on cellular and network models, in vitro electrophysiology on slices, and behavioral and electrophysiological studies in animals and humans. We welcome students or collaborators who share our goals and enthusiasm for the following themes of research:

Research Themes

  1. Context-specific behavioral strategies and adaptation to environmental changes:beraneck
    • Modulation of vestibulo-ocular and optokinetic reflexes.
    • Gravity’s influence on sensorimotor transformations.
    • Adaptation to hypergravity and weightlessness.
  2. Visuo-vestibular interactions and adaptation to sensory conflicts:
    • Dynamic of synaptic and intrinsic changes in vestibular adaptation.
    • Integration of vestibular and visual inputs for orientation: head direction cells.
    • Eye-hand coordination.
  3. Inner ear and central vestibular pathologies:
    • Developmental pathologies (congenital nystagmus; scoliosis; foetal cytomegalovirus syndrome; benign paroxys mal positional vertigo).
    • Acquired pathologies (Aged-related acuity loss; vestibular lesions).
    • Motion sickness and neuromodulation.

Collaborations

  • INRIA Rhônes-Alpes (Grenoble; France).
  • Mouse Clinical institute and IGBMC (Strasbourg; France).
  • French and European space agencies.
  • Istituto Italiano di Tecnologia (Genova; Italy).
  • Politecnico di Milano (Milan; Italy).
  • Tecnalia Health Technologies (San Sebastian; Spain).
  • Delft University of Technology (Delft; Holland).
  • University at Buffalo (Buffalo; US).

Team leaders

Members

Former members

See the list of former members

Recent Publications

2017 :


2016 :

2015 :

2014 :

2013 :

2012 :

2011 :

Books, chapters and patents