Cerebral Dynamics, Plasticity, Learning
The Cerebral Dynamics, Plasticity and Learning research group is an interdisciplinary team composed of theoreticians and experimentalists.
Our research addresses the functions and dysfunctions of neuronal networks in the cerebral cortex (visual, motor, frontal), the cerebellum and the basal ganglia (Parkinson disease, dystonias, autism, absence epilepsy).
Our work deals with systems at different levels of analysis, from synapses to neurons and from neurons to networks and interacting structures.
The theoretical works of the team rely on analytical calculations and numerical simulations of models that we investigate using techniques drawn from theoretical physics (e.g. statistical mechanics, bifurcation theory, extended nonlinear dynamical systems), information theory and stochastic processes theory. Our experimental works investigate neuronal activity using extracellular recordings in vivo (song bird), or patch-clamp in slices (cerebellum). We combine those electrophysiological methods with optogenetics and anatomical techniques including immunohistochemistry, neuronal tracing and counter-staining coloration.
For a true interdisciplinary research it is essential to report on our data, discuss papers and educate all our students in our different fields of expertise. Our team meets every week – from early September to end of July — for a general “group meeting”. We have also more specialized meetings: the “songbird journal club” and the “Integrate-or-fired” club which is a forum dedicated to tutorials on theoretical methods.
Themes of research
- Role of membrane receptors and channels in the development and plasticity of the cerebellum with a particular focus on the role of the cerebellum in the etiology of autism.
- Mechanistic aspects and functional implications of synaptic plasticity (short-term, long-term and structural) for collective network dynamics.
- Cellular and network mechanisms underlying synchronous activity and wave propagation in large neuronal ensembles.
- Emergence of the functional properties of neurons in the motor, visual and frontal cortices, basal ganglia and the cerebellum.
- Collective dynamics in the prefrontal cortex and and their role in working memory.
- Dynamics of the basal ganglia-thalamo-cortical loop its role in decision making and sensorimotor learning (e.g. song learning in birds) and its dysfunctions.
- Decision making and variability in behavior in experimentally controlled situations as well as in natural ones.
- Deciphering brain oxytocin circuits controlling social behavior. (Press release)
Our team organizes one day symposia on open questions in neuroscience.
Weekly group meeting
Our team organizes weekly meetings, you can access the schedule and reading list here.
The biweekly Integrate-or-fired meeting dedicated to the discussion of purely theoretical topics. The schedule can be found here.
We collaborate with colleagues from France (Bordeaux, Paris, Toulouse, Montpellier, Nice) and abroad (Jerusalem, Kyoto,Atlanta, Austin, Chicago, Philadelphia, Seattle, Vienna, Winston-Salem).
Our team is a pivotal component of the France Israel Laboratory in Neuroscience (FILN).
- A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning.
Pidoux L, Le Blanc P, Levenes C, Leblois A : Elife, 2018
- A long journey into reproducible computational neuroscience.
Topalidou M, Leblois A, Boraud T, Rougier NP : Front Comput Neurosci, 2015
- Asynchronous Rate Chaos in Spiking Neuronal Circuits.
Harish O, Hansel D : PLoS Comput Biol, 2015
- Modulation of Network Excitability by Persistent Activity: How Working Memory Affects the Response to Incoming Stimuli
Tartaglia EM, Brunel N, Mongillo G : PLoS Comput Biol, 2015
- Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors.
Ady V, Perroy J, Tricoire L, Piochon C, Dadak S, Chen X, Dusart I, Fagni L, Lambolez B, Levenes C : EMBO Rep, 2014
- Stimulus dependence of local field potential spectra: experiment versus theory.
Barbieri F, Mazzoni A, Logothetis NK, Panzeri S, Brunel N : J Neurosci, 2014
- PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer’s disease in the hippocampus and spatial memory impairments.
Chaalal A, Poirier R, Blum D, Gillet B, Le Blanc P, Basquin M, Buée L, Laroche S, Enderlin V : Hippocampus, 2014
- On the relationship between persistent delay activity, repetitionenhancement and priming
Tartaglia EM, Mongillo G, Brunel N : Front Psychol, 2014
- Interference and Shaping in Sensorimotor Adaptations with rewards.
Darshan R, Leblois A, Hansel D : PLoS Comput Biol, 2014
- The Misbehavior of Reinforcement Learning
Mongillo G, Shteingart H, Loewenstein Y : Proceedings of the IEEE, 2014
- The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons
Manuel M, Zytnicki D, Meunier C : Front Comput Neurosci, 2014
- Modified impact of emotion on temporal discrimination in a transgenic rat model of Huntington disease.
Faure A, Es-Seddiqi M, Brown BL, Nguyen HP, Riess O, von Hörsten S, Le Blanc P, Desvignes N, Bozon B, El Massioui N, Doyère V : Front Behav Neurosci, 2013
- Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory.
Penke Z, Morice E, Veyrac A, Gros A, Chagneau C, LeBlanc P, Samson N, Baumgärtel K, Mansuy IM, Davis S, Laroche S : Philos Trans R Soc Lond B Biol Sci, 2013
- Impact of spike train autostructure on probability distribution of joint spike events.
Pipa G, Grün S, van Vreeswijk C : Neural Comput, 2013
- Pointing to oneself : active versus passive proprioception revisited and implications for internal models of motor system function
Capaday C, Darling WG, Stanek K, van Vreeswijk C : Exp Brain Res, 2013
- On the functional organization and operational principles of the Motor Cortex
Capaday C, Ethier C, Darling WG, van Vreeswijk C : Front Neural Circuits, 2013
- Social modulation of learned behavior by dopamine in the basal ganglia : insights from songbirds.
Leblois A : J Physiol Paris, 2013
- Interaction between cognitive and motor cortico-basal ganglia loops during decision making : a computational study.
Guthrie M, Leblois A, Garenne A, Boraud T : J Neurophysiol, 2013
- Short-term plasticity explains irregular persistent activity in working memory tasks.
Hansel D, Mato G : J Neurosci, 2013
- Confidence levels during perceptual decision-making are discrete
Gorea A, Lisi M & Mongillo G : European Conference on Visual Perception, Barcelona, Spain, 2017