The Cere­bral Dynam­ics, Plas­tic­i­ty and Learn­ing research group is an inter­dis­ci­pli­nary team com­posed of the­o­reti­cians and exper­i­men­tal­ists.
Our research address­es the func­tions and dys­func­tions of neu­ronal net­works in the cere­bral cor­tex (visu­al, motor, frontal), the cere­bel­lum and the basal gan­glia (Parkin­son dis­ease, dys­to­nias, autism, absence epilep­sy).

Our work deals with sys­tems at dif­fer­ent lev­els of analy­sis, from synaps­es to neu­rons and from neu­rons to net­works and inter­act­ing struc­tures.

The the­o­ret­i­cal works of the team rely on ana­lyt­i­cal cal­cu­la­tions and numer­i­cal sim­u­la­tions of mod­els that we inves­ti­gate using tech­niques drawn from the­o­ret­i­cal physics (e.g. sta­tis­ti­cal mechan­ics, bifur­ca­tion the­o­ry, extend­ed non­lin­ear dynam­i­cal sys­tems), infor­ma­tion the­o­ry and sto­chas­tic process­es the­o­ry. Our exper­i­men­tal works inves­ti­gate neu­ronal activ­i­ty using extra­cel­lu­lar record­ings in vivo (song bird), or patch-clamp in slices (cere­bel­lum). We com­bine those elec­tro­phys­i­o­log­i­cal meth­ods with opto­ge­net­ics and anatom­i­cal tech­niques includ­ing immuno­his­to­chem­istry, neu­ronal trac­ing and counter-stain­ing col­oration.

For a true inter­dis­ci­pli­nary research it is essen­tial to report on our data, dis­cuss papers and edu­cate all our stu­dents in our dif­fer­ent fields of exper­tise. Our team meets every week – from ear­ly Sep­tem­ber to end of July — for a gen­er­al “group meet­ing”. We have also more spe­cial­ized meet­ings: the “song­bird jour­nal club” and the “Inte­grate-or-fired” club which is a forum ded­i­cat­ed to tuto­ri­als on the­o­ret­i­cal meth­ods.

Themes of research

• Role of mem­brane recep­tors and chan­nels in the devel­op­ment and plas­tic­i­ty of the cere­bel­lum with a par­tic­u­lar focus on the role of the cere­bel­lum in the eti­ol­o­gy of autism.
• Mech­a­nis­tic aspects and func­tion­al impli­ca­tions of synap­tic plas­tic­i­ty (short-term, long-term and struc­tur­al) for col­lec­tive net­work dynam­ics.
• Cel­lu­lar and net­work mech­a­nisms under­ly­ing syn­chro­nous activ­i­ty and wave prop­a­ga­tion in large neu­ronal ensem­bles.
• Emer­gence of the func­tion­al prop­er­ties of neu­rons in the motor, visu­al and frontal cor­tices, basal gan­glia and the cere­bel­lum.
• Col­lec­tive dynam­ics in the pre­frontal cor­tex and and their role in work­ing mem­o­ry.
• Dynam­ics of the basal gan­glia-thal­a­mo-cor­ti­cal loop its role in deci­sion mak­ing and sen­so­ri­mo­tor learn­ing (e.g. song learn­ing in birds) and its dys­func­tions.
• Deci­sion mak­ing and vari­abil­i­ty in behav­ior in exper­i­men­tal­ly con­trolled sit­u­a­tions as well as in nat­ur­al ones.
• Deci­pher­ing brain oxy­tocin cir­cuits con­trol­ling social behav­ior. (Press release)

Symposia Series 

Our team orga­nizes one day sym­posia on open ques­tions in neu­ro­science.

Weekly group meeting

Our team orga­nizes week­ly meet­ings, you can access the sched­ule and read­ing list here.

Integrate-or-fired club

The biweek­ly Inte­grate-or-fired meet­ing ded­i­cat­ed to the dis­cus­sion of pure­ly the­o­ret­i­cal top­ics. The sched­ule can be found here.

Collaborations

We col­lab­o­rate with col­leagues from France (Bor­deaux, Paris, Toulouse, Mont­pel­li­er, Nice) and abroad (Jerusalem, Kyoto,Atlanta, Austin, Chica­go, Philadel­phia, Seat­tle, Vien­na, Win­ston-Salem).

Our team is a piv­otal com­po­nent of the France Israel Lab­o­ra­to­ry in Neu­ro­science (FILN).

Recent Publications

Articles

• A sub­cor­ti­cal cir­cuit link­ing the cere­bel­lum to the basal gan­glia engaged in vocal learn­ing.
  Pidoux L, Le Blanc P, Lev­enes C, Leblois A : Elife, 2018
• A long jour­ney into repro­ducible com­pu­ta­tion­al neu­ro­science.
  Topali­dou M, Leblois A, Boraud T, Rougi­er NP : Front Com­put Neu­rosci, 2015
• Asyn­chro­nous Rate Chaos in Spik­ing Neu­ronal Cir­cuits.
  Har­ish O, Hansel D : PLoS Com­put Biol, 2015
• Mod­u­la­tion of Net­work Excitabil­i­ty by Per­sis­tent Activ­i­ty: How Work­ing Mem­o­ry Affects the Response to Incom­ing Stim­uli
  Tartaglia EM, Brunel N, Mongillo G : PLoS Com­put Biol, 2015
• Type 1 metabotrop­ic glu­ta­mate recep­tors (mGlu1) trig­ger the gat­ing of GluD2 delta glu­ta­mate recep­tors.
  Ady V, Per­roy J, Tri­coire L, Pio­chon C, Dadak S, Chen X, Dusart I, Fag­ni L, Lam­bolez B, Lev­enes C : EMBO Rep, 2014
• Stim­u­lus depen­dence of local field poten­tial spec­tra: exper­i­ment ver­sus the­o­ry.
  Bar­bi­eri F, Maz­zoni A, Logo­thetis NK, Panz­eri S, Brunel N : J Neu­rosci, 2014
• PTU-induced hypothy­roidism in rats leads to sev­er­al ear­ly neu­ropatho­log­i­cal signs of Alzheimer’s dis­ease in the hip­pocam­pus and spa­tial mem­o­ry impair­ments.
  Chaalal A, Poiri­er R, Blum D, Gillet B, Le Blanc P, Basquin M, Buée L, Laroche S, Ender­lin V : Hip­pocam­pus, 2014
• On the rela­tion­ship between per­sis­tent delay activ­i­ty, rep­e­ti­tio­nen­hance­ment and prim­ing
  Tartaglia EM, Mongillo G, Brunel N : Front Psy­chol, 2014
• Inter­fer­ence and Shap­ing in Sen­so­ri­mo­tor Adap­ta­tions with rewards.
  Dar­shan R, Leblois A, Hansel D : PLoS Com­put Biol, 2014
• The Mis­be­hav­ior of Rein­force­ment Learn­ing
  Mongillo G, Shtein­gart H, Loewen­stein Y : Pro­ceed­ings of the IEEE, 2014
• The den­drit­ic loca­tion of the L-type cur­rent and its deac­ti­va­tion by the somat­ic AHP cur­rent both con­tribute to fir­ing bista­bil­i­ty in motoneu­rons
  Manuel M, Zyt­nic­ki D, Meu­nier C : Front Com­put Neu­rosci, 2014
• Mod­i­fied impact of emo­tion on tem­po­ral dis­crim­i­na­tion in a trans­genic rat mod­el of Hunt­ing­ton dis­ease.
  Fau­re A, Es-Sed­diqi M, Brown BL, Nguyen HP, Riess O, von Hörsten S, Le Blanc P, Desvi­gnes N, Bozon B, El Mas­sioui N, Doyère V : Front Behav Neu­rosci, 2013
• Zif268/Egr1 gain of func­tion facil­i­tates hip­pocam­pal synap­tic plas­tic­i­ty and long-term spa­tial recog­ni­tion mem­o­ry.
  Penke Z, Morice E, Veyrac A, Gros A, Chag­neau C, LeBlanc P, Sam­son N, Baumgär­tel K, Man­suy IM, Davis S, Laroche S : Phi­los Trans R Soc Lond B Biol Sci, 2013
• Impact of spike train autostruc­ture on prob­a­bil­i­ty dis­tri­b­u­tion of joint spike events.
  Pipa G, Grün S, van Vreeswijk C : Neur­al Com­put, 2013
• Point­ing to one­self : active ver­sus pas­sive pro­pri­o­cep­tion revis­it­ed and impli­ca­tions for inter­nal mod­els of motor sys­tem func­tion
  Capa­day C, Dar­ling WG, Stanek K, van Vreeswijk C : Exp Brain Res, 2013
• On the func­tion­al orga­ni­za­tion and oper­a­tional prin­ci­ples of the Motor Cor­tex
  Capa­day C, Ethi­er C, Dar­ling WG, van Vreeswijk C : Front Neur­al Cir­cuits, 2013
• Social mod­u­la­tion of learned behav­ior by dopamine in the basal gan­glia : insights from song­birds.
  Leblois A : J Phys­i­ol Paris, 2013
• Inter­ac­tion between cog­ni­tive and motor cor­ti­co-basal gan­glia loops dur­ing deci­sion mak­ing : a com­pu­ta­tion­al study.
  Guthrie M, Leblois A, Garenne A, Boraud T : J Neu­ro­phys­i­ol, 2013
• Short-term plas­tic­i­ty explains irreg­u­lar per­sis­tent activ­i­ty in work­ing mem­o­ry tasks.
  Hansel D, Mato G : J Neu­rosci, 2013

Speech communication

• Con­fi­dence lev­els dur­ing per­cep­tu­al deci­sion-mak­ing are dis­crete (PDF)
  Gorea A, Lisi M & Mongillo G : Euro­pean Con­fer­ence on Visu­al Per­cep­tion, Barcelona, Spain, 2017