
Centre de Neurophysique, Physiologie et Pathologie — CNRS UMR 8119
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France
Fax : +33 (0) 1 42 86 20 80
Dr. Marin MANUEL
CNRS researcher, CR-CNRS
Spinal physiology and pathophysiology
marin.manuel@-Code to remove to avoid SPAM-parisdescartes.fr
+33 1 42 86 33 56, room H333C
Recent Publications
Articles
- Time course of alterations in adult spinal motoneuron properties in the SOD1(G93A) mouse model of ALS.
Huh S, Heckman CJ, Manuel M : ENeuro, 2021 - Sub-optimal Discontinuous Current-Clamp switching rates lead to deceptive mouse neuronal firing.
Manuel M : ENeuro, 2021 - Synaptic Restoration by cAMP/PKA Drives Activity-Dependent Neuroprotection to Motoneurons in ALS
Bączyk M, Alami NO, Delestrée N, Martinot C, Tang L, Commisso B, Bayer D, Doisne N, Frankel W, Manuel M, Roselli F, Zytnicki D : J Exp Med, 2020 - Molecular and electrophysiological properties of mouse motoneuron and motor unit subtypes
Manuel M, Zytnicki D : Current Opinion in Physiology, 2019 - Scaling of Motor Output, From Mouse to Humans.
Manuel M, Chardon M, Tysseling V, Heckman CJ : Physiology (Bethesda), 2019 - Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS.
Martínez-Silva ML, Imhoff-Manuel RD, Sharma A, Heckman CJ, Shneider NA, Roselli F, Zytnicki D, Manuel M : Elife, 2018 - Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve.
Hichor M, Sundaram VK, Eid SA, Abdel-Rassoul R, Petit PX, Borderie D, Bastin J, Eid AA, Manuel M, Grenier J, Massaad C : Sci Rep, 2018 - Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion.
Bos R, Harris-Warrick RM, Brocard C, Demianenko LE, Manuel M, Zytnicki D, Korogod SM, Brocard F : Cell Rep, 2018 - Constitutive activity of 5‑HT receptors is present after incomplete spinal cord injury but is not modified after chronic SSRI or baclofen treatment.
Tysseling VM, Klein DA, Imhoff-Manuel R, Manuel M, Heckman CJ, Tresch MC : J Neurophysiol, 2017 - PICs in motoneurons do not scale with the size of the animal: a possible mechanism for faster speed of muscle contraction in smaller species.
Huh S, Siripuram R, Lee RH, Turkin VV, O\\’Neill D, Hamm TM, Heckman CJ, Manuel M : J Neurophysiol, 2017 - Decerebrate mouse model for studies of the spinal cord circuits.
Meehan CF, Mayr KA, Manuel M, Nakanishi ST, Whelan PJ : Nat Protoc, 2017 - Absence of UCHL 1 function leads to selective motor neuropathy.
Genç B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, Özdinler PH : Ann Clin Transl Neurol, 2016 - MuSK frizzled-like domain is critical for mammalian neuromuscular junction formation and maintenance.
Messéant J, Dobbertin A, Girard E, Delers P, Manuel M, Mangione F, Schmitt A, Le Denmat D, Molgó J, Zytnicki D, Schaeffer L, Legay C, Strochlic L : J Neurosci, 2015 - Adult spinal motoneurones are not hyperexcitable in a mouse model of inherited amyotrophic lateral sclerosis
Delestrée N, Manuel M, Iglesias C, Elbasiouny SM, Heckman CJ, Zytnicki D : J Physiol, 2014 - The dendritic location of the L‑type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons
Manuel M, Zytnicki D, Meunier C : Front Comput Neurosci, 2014 - Characterization of motor units in behaving adult mice shows a wide primary range
Ritter LK, Tresch MC, Heckman CJ, Manuel M, Tysseling VM : J Neurophysiol, 2014 - Push-pull control of motor output
Johnson MD, Hyngstrom AS, Manuel M, Heckman CJ : J Neurosci, 2012 - NMDA induces persistent inward and outward currents that cause rhythmic bursting in adult rodent motoneurons
Manuel M, Li Y, Elbasiouny SM, Murray K, Griener A, Heckman CJ, Bennett DJ : J Neurophysiol, 2012 - Simultaneous intracellular recording of a lumbar motoneuron and the force produced by its motor unit in the adult mouse in vivo
Manuel M, Heckman CJ : J Vis Exp, 2012 - Mixed mode oscillations in mouse spinal motoneurons arise from a low excitability state.
Iglesias C, Meunier C, Manuel M, Timofeeva Y, Delestrée N, Zytnicki D : J Neurosci, 2011 - Stronger is not always better: could a bodybuilding dietary supplement lead to ALS?
Manuel M, Heckman CJ : Exp Neurol, 2011 - Extra forces evoked during electrical stimulation of the muscle or its nerve are generated and modulated by a length-dependent intrinsic property of muscle in humans and cats
Frigon A, Thompson CK, Johnson MD, Manuel M, Hornby TG, Heckman CJ : J Neurosci, 2011 - Alpha, beta and gamma motoneurons: functional diversity in the motor system’s final pathway
Manuel M, Zytnicki D : J Integr Neurosci, 2011 - Adult mouse motor units develop almost all of their force in the subprimary range: a new all-or-none strategy for force recruitment?
Manuel M, Heckman CJ : J Neurosci, 2011 - Fast kinetics, high-frequency oscillations, and subprimary firing range in adult mouse spinal motoneurons.
Manuel M, Iglesias C, Donnet M, Leroy F, Heckman CJ, Zytnicki D : J Neurosci, 2009 - Resonant or not, two amplification modes of proprioceptive inputs by persistent inward currents in spinal motoneurons.
Manuel M, Meunier C, Donnet M, Zytnicki D : J Neurosci, 2007 - The afterhyperpolarization conductance exerts the same control over the gain and variability of motoneurone firing in anaesthetized cats.
Manuel M, Meunier C, Donnet M, Zytnicki D : J Physiol, 2006 - How much afterhyperpolarization conductance is recruited by an action potential? A dynamic-clamp study in cat lumbar motoneurons.
Manuel M, Meunier C, Donnet M, Zytnicki D : J Neurosci, 2005