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Cen­tre de Neu­ro­physique, Phys­i­olo­gie et Patholo­gie — CNRS UMR 8119
Uni­ver­sité Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 20 80

Dr. Boris LAMOTTE D’INCAMPS

CNRS researcher, CR-CNRS
Spinal phys­i­ol­o­gy and patho­phys­i­ol­o­gy

boris.lamotte-incamps@-Code to remove to avoid SPAM-parisdescartes.fr
+33 1 42 86 20 58, room H333B

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Research Inter­ests

My research activ­i­ty is focussed on the phys­i­ol­o­gy of nor­mal and patho­log­i­cal spinal motor neu­rons. This includes their intrin­sic prop­er­ties as well as the spinal cir­cuits which con­trol their activ­i­ty.

Cur­rent­ly, I am work­ing on the recur­rent inhi­bi­tion of spinal motoneu­rons (the neu­rons respon­si­ble for mus­cle con­trac­tion). This di-synap­tic path­way involves i) the synapse of the recur­rent col­lat­er­al of the motoneu­ron axons that excites  the Ren­shaw cells, and ii) the inhibito­ry synappse between the Ren­shaw cells and the motoneu­rons (see Fig­ure). Although this was the first inhibito­ry cir­cuit to be stud­ied in the ver­te­brate cen­tral ner­vous sys­tem (Ren­shaw 19411946, Eccles et al. 1954), we still do not under­stand its func­tion (for reviews see Wind­horst 1996, Alvarez and Fyffe 2007). In col­lab­o­ra­tion with P. Asch­er (CNRS UMR 8118, Paris), we stud­ied the phar­ma­co­log­i­cal prop­er­ties of the synapse between the recur­rent axon­al col­lat­er­al of motoneu­rons and Ren­shaw cells. We demon­strat­ed that the recur­rent synapse acti­vates at least four types of ionotrop­ic recep­tors, in par­tic­u­lar, acetyl­choline α7 recep­tors and glu­ta­mate NMDA  recep­tors. The char­ac­ter­is­tics of these synap­tic cur­rents led us to pro­pose that the Ren­shaw cell response may switch between a short high fre­quen­cy burst and a longer ton­ic dis­charge (Lam­otte d’Incamps and Asch­er 2008). We are now inves­ti­gat­ing the spillover of acetyl­choline at this synapse and the effi­cien­cy of its con­trol by the enzy­mat­ic degra­da­tion of the neu­ro­trans­mit­ter.

Fig - 1

Recent­ly, in a the­o­ret­i­cal study with Claude Meu­nier, we have extend­ed the cable the­o­ry to allow the descrip­tion of het­ero­geneities along the den­drites (or axons) of neu­rons. This work allowed us to link the influ­ence of het­ero­geneities of the mor­pho­log­i­cal and elec­tri­cal prop­er­ties of neu­rons to their inte­gra­tive prop­er­ties (Meu­nier and Lam­otte d’Incamps 2008).

In col­lab­o­ra­tion with J. Durand (CNRS UMR 6196, Mar­seille, France) we have com­pared the elec­tri­cal prop­er­ties of lum­bar motoneu­rons from mice trans­fect­ed with the human mutat­ed gene SOD1, con­sid­ered as a mod­el of Amy­otroph­ic Lat­er­al scle­ro­sis (ALS), with the motoneu­ron prop­er­ties of con­trol mice (Bories et al. 2007).

 

Recent Publications

Articles